Generic Name: Metronidazole 250mg
Manufacturer: Incepta Pharmaceuticals Ltd.
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Indications
An antibiotic drug called Flamyd 250 aids your body in battling parasitic and bacterial illnesses. It is used to treat infections of the skin, bones, brain, heart, lungs, stomach, intestines, and vagina. After surgery, Flamyd 250 helps prevent infection. Additionally, it is used to treat leg ulcers, pressure sores, and tooth infections. It is preferable to take this medication after a meal. To reap the greatest benefits, it should be taken at the same time every day. Depending on what you are being treated for and how severe it is, your doctor will advise you on how much to take, but you must take this antibiotic exactly as directed.
Pharmacology
Metronidazole is an antibacterial medication that belongs to the imidazole family and is used as an antiprotozoal agent. Anaerobes decrease the 5-nitro group of Metronidazole metabolically. Metronidazole's bactericidal effect is due to the reduced form of the antibiotic interacting with DNA, according to studies.
These conditions are all treated with metronidazole:
Dosage & Administration
Tablet and Suspension:
Trichomoniasis (Adults & Children over 10 yrs)-
Trichomoniasis (Children)-
Intestinal amoebiasis (Adults & Children over 10 yrs)-
Intestinal amoebiasis (Children)-
Extra-intestinal & Asymptomatic amoebiasis (Adults & Children over 10 yrs)-
Extra-intestinal & Asymptomatic amoebiasis (Children)-
Giardiasis (Adults & Children over 10 yrs)-
2 gm once daily for 3 days
Giardiasis (Children)-
Acute ulcerative gingivitis (Adults & Children over 10 yrs)-
200 mg tid for 3 days
Acute ulcerative gingivitis (Children)-
Acute dental infections (Adults & Children over 10 yrs)-
Bacterial Vaginosis (Adults & Children over 10 yrs)-
Leg ulcers and pressure sores (Adults & Children over 10 yrs)-
Anaerobic infections (Adults & Children over 10 yrs)-
Anaerobic infections (Children)-
Surgical prophylaxis (Adults & Children over 10 yrs)-
Surgical prophylaxis (Children)-
Vaginal Gel:
One applicator full of metronidazole gel, or around 5 grams and 37.5 milligrams of metronidazole, should be injected intravaginally once or twice a day for five days. Metronidazole gel should be taken at bedtime for a single daily dose.
Suppository:
Anaerobic Infections-
Surgical Precautions
IV Infusion:
Adults and children over 12 years:
Children younger than 12 years old:
Interaction
Use in conjunction with disulfiram may result in psychotic responses. The impact of oral anticoagulants may be enhanced. may make lithium poisoning more likely. Can increase the 5-fluorouracil's toxicity by decreasing renal clearance. may raise ciclosporin levels in the blood. may lead to a significant increase in busulfan plasma levels and severe busulfan toxicity. reduced serum concentrations as a result of phenobarbital and phenytoin's enhanced metabolism.
Contraindications
Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
Side Effects
Metallic taste
Nausea
Vomiting
Diarrhea
Drowsiness
Rashes may be observed during treatment.
Pregnancy & Lactation
Metronidazole is classified as a pregnancy category B by the US Food and Drug Administration. However, no appropriate and well-controlled trials in pregnant women have been conducted. Because animal reproduction studies do not always anticipate a human response, this medication should only be taken during pregnancy if absolutely necessary. Human milk has been found to contain metronidazole. When Metronidazole is given to a breastfeeding mother, care should be used.
Precautions & Warnings
If metronidazole must be given for a longer period of time than is typically suggested, it is recommended that hematological tests, particularly leucocyte counts, be performed on a regular basis and that patients be watched for adverse responses such as peripheral or central neuropathy (such as paresthesia, ataxia, dizziness, convulsive seizures). Inform your doctor if you have liver disease. Your dose may need to be adjusted in severe liver disease.
Patients with hepatic encephalopathy should be given metronidazole with care.
Metronidazole might cause urine to discolor, therefore patients should be informed.
Storage Conditions
Keep it below 30°C. Protect yourself from the sun. Medicines should be kept out of the reach of youngsters. Do not use it beyond the expiration date.
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